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The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I

When mycotoxins impair the electron transport chain, the mitochondria begin to leak reactive oxygen species (ROS), causing severe oxidative stress

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So, when you take Pynocare for your melasma concerns, you are also exposed to the same external conditions (weather, environment, etc.) as to the subjects in the study