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It also advises against vitamin E for the prevention of cardiovascular disease and cancer, and warns of the potential risks of vitamin or mineral supplementation in general, recommending instead a healthy, balanced diet.78 The risks and benefits of systemic skin aging treatments must be carefully weighed up, as their purpose is to reverse or slow down a natural process rather than treat a particular disease

43 With regard to HF with preserved ejection fraction (HFpEF), initial data suggest a benefit of tirzepatide and semaglutide in patients with obesity

Theyve tried to do some of that on the state level

Studies have shown that GLP-1RA affects the key phases by reducing its main cytokines and chemokines, such as TNF, IL-6, IL-10, and IL-12, and MCP-1, leading to a reduced inflammatory state, improved endothelial function, and promoted cholesterol efflux