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TICs maintain lower intracellular ROS levels than other cancer cells within the tumor, primarily through the accumulation of ROS scavengers like glutathione and the overexpression of Gclm and glutathione synthetase, the enzymes necessary for its synthesis, as shown in breast and liver cancer stem cells [18, 20]

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Reishi and grape seed , for example, can interact with blood thinners and other medications, and their blood-pressure-lowering effects may make them unsuitable for anyone already taking blood pressure medicine.100 101 These two ingredients are by no means the only ones with contraindications, either