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Mann is a diplomate of the American Board of Obesity Medicine and a certified menopause practitioner (MSCP) through The Menopause Society

The science of slowed gastrointestinal motility GLP-1 receptor agonists act on the gutbrain axis and are known to slow gastric emptying and overall gastrointestinal transit , contributing to early satiety and appetite suppression. As intestinal transit slows, the colon has more time to absorb water from stool , leading to hard, dry stools that are difficult to pass . Constipation is a common, dose-related adverse effect listed in FDA prescribing information for both Wegovy (semaglutide) and Zepbound (tirzepatide) and is most frequently reported during dose escalation , with improvement over time., Step-by-Step MD Protocol for Relief 1

Remember that compounded medications follow the Beyond Use Date (BUD) protocol, while branded pens have a 21-day limit once they reach room temperature

The numbers are comparable in direction, not in scientific equivalence