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Indeed the GLP-1(7-36) NH2 receptor, a GPCR, is found to be expressed by a wide range of tissues and cells such as: , , and -cells (169), sinoatrial node myocytes, arterial smooth muscle cells of lungs and kidneys, megakaryocytes, macrophages, monocytes, lymphocytes, gastrointestinal tract mucosa [mainly Brunner's gland in the duodenum, but also in the parietal cells of the stomach, jejunum ileum and the nerve plexus around the small and large intestine (170, 171)], central nervous system [neocortex, cerebellum, thalamus, amygdala, area postrema, hypothalamus, hippocampus, nucleus tractus solitarius (158)], peripheral nervous system (myenteric plexus) and in the skin (14, 172176)

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