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Originally developed to treat Type 2 diabetes, GLP-1 medications are now widely used for weight management

GLP-1 Inhibitor Reduces Knee Osteoarthritis Pain Save Semaglutide (Wegovy) reduced pain and improved physical function in patients with obesity and knee osteoarthritis, a randomized trial showed

Additionally, they inhibit the secretion of glucagon, a hormone that raises blood sugar levels, and slow gastric emptying, leading to a prolonged feeling of fullness and reduced appetite

The most detailed population-level analysis comes from Wharton et al., published in Diabetes, Obesity and Metabolism in 2021, which pooled data from the STEP 13 trials