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Effexor XRs label warns that the drug should be used by expectant mothers only if clearly needed. Babies exposed to Effexor and other antidepressants during the third trimester of pregnancy have been born with significant problems, including: Bluish discoloration from poor oxygenation Floppy or rigid muscle tone Irritability, jitteriness and constant crying Low blood sugar levels Respiratory distress Temporary pauses in breathing Trouble feeding Trouble maintaining body temperature Vomiting According to Effexors label, these complications may represent withdrawal symptoms, serotonin syndrome or other toxic side effects of the drug