It's the first 'to directly compare the efficacy and safety of two oral GLP-1 receptor agonists in a randomised controlled trial', reports Medscape. The part about 'directly comparing' the two drugs is important
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In a next step, the significant [11C]Raclopride displacement cluster was used as an ROI to extract individual TACs for which the lp-ntPET model was fitted again to yield dynamic BP ND estimate curves which were transformed to DA receptor occupancy: This two-step approach is done to reduce the noise inherent in the single voxel TACs
In e and f , these residues are buried, and thus are not visible, while in g , exposure of these residues provides space for the G protein to bind
