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Zonulin creates spaces in the junctions of the gut and by tightening up these spaces, intestinal barrier function can be restored

Notably, engineered EVs show promise as biocompatible drug carriers to overcome therapeutic resistance [53,54] , with strategies like peptide-functionalized bacterial EVs demonstrating targeted miRNA delivery efficacy in bone diseases [58] , reinforcing the potential of engineered EVs to overcome therapeutic resistance

This modification reduces renal clearance, theoretically allowing lower daily doses to maintain sustained serum levels

Injectable peptides These are administered deeper into the skin, allowing the ingredients to be delivered directly in the dermis (the deeper skin layer)