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Rather than pushing toward the maximum dose used in obesity trials, a clinician might: Start at a lower dose than usual Increase more slowly or pause increases for longer Stop escalating when acceptable appetite control and side-effect balance are reached, even if the dose is below the typical obesity dose This is where terms like microdosing guide and microdose guide show up online

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Studies in murine models indicate that IGF-1 LR3 may be cleared from the plasma faster, to be destributed more quickly into various tissue models as compared to IGF-1