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Serum B12 alone can sometimes be misleading MMA levels provide a more functional assessment of whether your body is actually utilizing the B12 available to it

Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

By blocking NNMT, you're keeping visceral fat cells in a more reactive state even as overall caloric restriction continues