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Payers are likely to have restrictive coverage criteria to restrict initial access to patients with highest clinical need, including BMI greater than 35 kg/m, multiple obesity-related comorbidities, and poor response to GLP-1 monotherapy

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Understanding these fundamentals helps contextualize why some individuals appear to have naturally "fast" or "slow" metabolisms and whether these differences stem from inherited traits or other modifiable factors

Accessed Apr 10, 2025