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Commensal bacteria perform a variety of functions, one of which is enhancing the intestinal epithelial barrier (8, 8, .The gutkidney crosstalk is about how CKD, the digestive system, and changes in the permeability of the intestinal epithelial barrier affect each other ( (IFN-), TNF- , and IL-6 ( Additionally, the uremic milieu that results in elevated expression of TLR2 and TLR4 may be the reason why neutrophils and monocytes from CKD patients exhibit an excessive response to stimulation with lipopolysaccharides (LPS) ( In order to maintain the balance of the gastrointestinal system, it is crucial to stimulate the development of mucosal immune responses