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In studies of mice with transplanted human breast tumor tissue, concurrent treatment of either vitamin A or beta-carotene with cyclophosphamide led to a significantly greater tumor response and survival time compared to cyclophosphamide treatment alone

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Evidence also suggested that HD has significant positive effects on liver morphology and structure, inflammation, fibrosis, and oxidative stress in rats with bile duct ligation (BDL)-induced cholestatic liver injury by decreasing the levels of inflammatory gene expression and increasing the levels of total antioxidant capacity (Nasehi et al., 2023)