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The activated receptor also recruits beta-arrestins, which dampen G protein signaling and draw the receptor inside the cell, a process that controls how long and how strongly the receptor fires

Castilhos LG, et al

Evidence for Kidney Benefits Clinical trials show consistent kidney benefits: FLOW trial (semaglutide): This dedicated kidney outcome trial showed semaglutide reduced the risk of major kidney outcomes (kidney failure, significant decline in kidney function, or kidney-related death) by 24% in diabetic patients with chronic kidney disease