ICER found the drugs deliver value at current prices but estimated that treating even 1 percent of eligible patients would exceed its $880 million annual budget impact threshold
10.1126/science.aap7847 Science Summary Keywords malaria, Plasmodium berghei , glutathione S-transferase, drug target, structure-based screening, shape similarity screening, antimalarial drug discovery, predicted pharmacokinetic and toxicity parameters Citation Coln-Lorenzo EE, Coln-Lpez DD, Vega-Rodrguez J, Dupin A, Fidock DA, Baerga-Ortiz A, Ortiz JG, Bosch J and Serrano AE (2020) Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound
Udler M, Maia AT, Cebrian A, Brown C, Greenberg D, Shah M, Caldas C, Dunning A, Easton D, Ponder B, Pharoah P
[DOI] [PubMed] [Google Scholar] 14.Calissendorff J., Mikulski E., Larsen E.H., Mller M