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Equally, there is now increased recognition of the part that molecular and genetic factors play in the etiology of thyroid cancers, but one of the key research gaps continues to be a lack of reliable biomarkers for distinguishing benign from malignant thyroid lesions

We found that AAV-mediated knockdown of hepatic CYP8B1 could block the T3 effects on the GLP-1 production, insulin and glucose levels, and oral glucose tolerance in either hypothyroid or euthyroid mice (Fig