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Moreover, with the rapid endothelium maintenance as the key for a pleiotropic beneficial effect, there is a particular emphasis on the capacity of a large wound to heal itself [1,9], due to both its epithelium and endothelium integrity maintenance capabilities

In experimental models, the peptide components associated with KLOW influence immune-cell trafficking by modulating inflammatory mediators, endothelial signaling, and chemotactic pathways

For example, increased concentrations of primary plasma bile acids have been reported after RYGB, while this effect has not been seen after adjustable gastric banding [110, 111]

Ebselen has also been formulated to nanoemuslsions that showed antifungal activity against vulvovaginal candidiasis in a mouse model (Menon et al., 2021)