semaglutide hiv NEJM - for HIV-associated lipohypertrophy: This GLP-1 receptor agonist decreased abdominal fat but also appeared to reduce lean body mass. https://jwat.ch/3zJCodJ ACC 2025: Oral Semaglutide Reduces

What also matters is that this is the data Novo Nordisk submitted to the FDA and the FDA chose to include in the prescribing information - meaning regulators considered it relevant for healthcare providers and patients to know

Dose Range: 5001000 mcg daily with gradual titration (~5 mg/week average)

In addition, clinical muscle function studies involving older men and women have observed that participants in the placebo group show declines in muscle strength over the course of the study [40, 41], relative to baseline, similar to this current report

While expected quantitative differences due to dataset composition and integration were present, these results were consistent with the main findings