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The final determination will depend on the overall risk-benefit profile established in large-scale, long-term cardiovascular outcome trials

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Vascular NOXs are regulated by a peptide-hormone, Angiotensin II (AngII) that stimulates the formation of NOX-dependent ROS which in turn activate Angiotensin II receptor type 1 (AT1) with a self-strengthening effect (Santillo et al

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The expectation is informed extrapolation, not a published headline

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Prescription-strength, not the watered-down serums sold at a store

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