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Consistent with the human PK data, we observed that the plasma half-life of GLP-1 WT in transgenic mice expressing human FcRn was 1.8-fold shorter than that of unfused WT albumin

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The AngioSafe 1 study, which is also designed to clarify the association between exposure to GLP-1R agonists and diabetic retinopathy through clinical and preclinical study designs found no risk for severe diabetic retinopathy when patients were treated with GLP-1R agonists, and no effect of GLP-1R agonists on angiogenesis (Gaborit et al., 2020)