La administracin perifrica de LIRA se sigue de su localizacin a nivel de los rganos circunventriculares y el ncleo arcuato hipotalmico, donde favorece la activacin de vas anorexignicas e inhibicin de las orexignicas, merced a la estimulacin de neuronas productoras de Pro-opiomelanocortina/Transcripto cocana-anfetamina (POMC/CART) y la inhibicin indirecta del eje orexiante NeuropptidoY/Protena relacionada con Agouti (NPY/AgRP) a travs de mecanismos gabargicos18
Heres how it works: Mechanism of Action GLP-1 Receptor Agonism: Like other GLP-1 receptor agonists, Tirzepatide enhances insulin secretion in response to meals, suppresses glucagon release (which decreases glucose production by the liver), slows gastric emptying, and promotes satiety, which can lead to reduced food intake and weight loss
It is intended exclusively for in vitro laboratory research use
A behavioural neuroscientist by training, Sophie has spent 30 years working at the intersection of medical research, pharmacology, technology and patient communication across the pharmaceutical industry, health technology and charity sectors
