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10.1073/pnas.0507498102 31 NoctorG.MhamdiA.ChaouchS.HanY.NeukermansJ.Marquez-GarciaB.et al

The changes in GSH levels induced by such stress are instantaneous and drastic processes, while the generation and replenishment of GSH require a lengthy process, due to involving the rate-limiting indicator glutathione synthetase [43]

MCP-1 levels in sleep-deprived mice treated with GHK were significantly lower in the CA3 region of the hippocampus compared to sleep-deprived mice treated with saline, indicating GHKs anti-inflammatory effect (Figure 2A)