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Moreover, despite statistical significance, the improvements did not reach minimal clinically important difference (MCID) thresholds for all patients (Ghorbani et al., 2024)
A prespecified nephrology analysis showed a 22% relative risk reduction in the composite renal endpoint (new macro-albuminuria, doubling of serum creatinine, dialysis, or renal death) driven mainly by a 26% fall in new-onset macro-albuminuria [8, 36]
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