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Reconstituted product should be kept refrigerated and used promptly.

Short-term studies of up to 7 days have found that L-citrulline malate supplementation improves skeletal muscle metabolism and that the combination of L-citrulline and reduced glutathione (GSH) boosts plasma levels of L-citrulline, L-arginine and nitric oxide metabolites compounds that support muscle mass

Some patients also experience mild injection site reactions like redness or swelling

Patients prescribed the 2.5 mg starting dose should be aware that BCBS plans typically authorize the full titration schedule (2.5 mg for 4 weeks, then 5 mg, then potential increases to 7.5 mg, 10 mg, 12.5 mg, or 15 mg) under one PA approval