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As we look to 2026, the story becomes one of defining firsts: the debut of oral GLP-1s, the first loss of exclusivity for a GLP-1 receptor antagonist, and landmark coverage decisions such as obesity medications entering Medicare formularies for obesity as a standalone indication

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When applied during peak activity periods (nocturnal phase), VNS suppresses pro-inflammatory gene expression (e.g., IL-6), reduces inflammatory responses, and enhances BBB integrity through upregulation of ZO-1 and occluding (152, 158)

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