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Second, its interaction with amino acid metabolism: intermediates of glucose metabolism and the tricarboxylic acid (TCA) cycle provide carbon skeletons for amino acid synthesis and transformation, while also modulating NADH levels, thereby influencing GSH production (103)

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For Skin Brightening- L-Glutathione inhibits the skin's coloration with melanin by blocking the tyrosinase enzyme needed for melanin synthesis

The explanation for this discrepancy can be found in recent papers showing that some cancer cell linesincluding HCT116are not affected by L-BSO or GSH synthesis inactivation because they can compensate GSH depletion by the thioredoxin (TXN) pathway 25 , and by maintaining protein homeostasis through deubiquitinating enzymes (DUB) 32