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(PubMed) Powolny AA, Singh SV

Pendulum GLP-1 Probiotic is formulated by a team of PhD scientists from Johns Hopkins, Harvard, Berkeley and Stanford backed by Mayo Clinic, Sequoia Capital and over $111 million in research investment combining Akkermansia muciniphila with complementary probiotic strains specifically selected to support gut barrier integrity, microbiome diversity and the gut signalling environment associated with appetite and craving management

The FDA approved GLP-1s after testing them in large clinical trials (such as STEP and SURMOUNT ) at specific doses and intervals

Thirty-two overweight or moderately obese men were treated with tesofensine or a placebo for two weeks