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When these receptors are over-activated by excess glutamatea common consequence of systemic inflammationit leads to a state of excitatory neurotoxicity

2015 Jun 8;10(6):e0129605

3.4 Regulation of NF-B signaling Nuclear factor B (NF-B) is a key transcription factor that regulates various physiological and pathological processes, such as inflammation, immunity, cell survival, and death

For example, remicade, a clinically used anti-TNF- antibody targeting the p50 and p65 NF-B subtype of small interfering RNA and curcumin, a well-characterized natural NF-B inhibitor that is also a dominant negative inhibitor of B (IB), can inhibit GGT activation through distinct mechanisms