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MK-677 mimics ghrelins action to stimulate GH release, whereas Ipamorelin directly stimulates GH release

Miller R, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock : Methionine deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-1 and insulin levels and increases hepatocyte MIF levels and stress resistence

J Clin Endocrinol Metab (1996) 81(2):4605.10.1210/jcem.81.2.8636250 246 LiuHBravataDMOlkinINayakSRobertsBGarberAMet alSystematic review: the safety and efficacy of growth hormone in the healthy elderly