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M.HuelskenJ.JerchowB.et al (2009)

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in the fourth step, an octane silane bonded silica gel filler serves as a fixed phase, an ammonium acetate solution serves as a mobile phase A, acetonitrileserves as a mobile phase B, and secondary HPLC purification is conducted so as to remove impurities having the similar physical and chemical properties as sermaglutide

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