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Similarly, ABL kinase inhibitors such as imatinib protect oocytes by blocking c-Ablmediated phosphorylation of the pro-apoptotic factor TAp63, a pivotal executioner of DNA-damage-induced oocyte death

In PCOS where insulin resistance is present in up to 80% of affected women regardless of body weight GLP-1 agonists have demonstrated measurable reductions in free testosterone, improved menstrual regularity, and significant metabolic benefit

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