Introduction Itraconazole (ITZ) is an azole antifungal drug used to treat a variety of fungal infections in dogs, including dermatophytosis, malasseziosis, systemic mycoses such as blastomycosis and histoplasmosis, and mycoses caused by opportunistic fungi ( In veterinary medicine, ITZ is effective in treating systemic infections with Blastomyces dermatitidis, Histoplasma capsulatum, Cryptococcus neoformans , and Coccidioides immitis , among others ( Despite its efficacy, ITZ is associated with a number of adverse reactions in dogs including nausea, vomiting, lethargy, anorexia, ulcerative dermatitis, and hepatotoxicity ( Mechanisms of ITZ-associated hepatotoxicity in people and animals are poorly understood
While they are powerful tools for weight loss, there's a fine line between benefit and risk
For example, women with obesity were more predisposed to severe L-C19 at one year after discharging due to hormonal, pro-inflammatory and metabolic state (176)
The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)
