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SHR rats originated at the Kyoto School of Medicine in 1963, where Okamoto mated an outbred Wistar Kyoto male with marked elevation of blood pressure to a female with slightly elevated blood pressure [24]

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The eight items of the Positive and Negative Syndrome Scale capturing the core symptoms critical in defining remission (PANSS-8 [39]) was administered at baseline, 2 weeks, 4 weeks, and at every clinical encounter thereafter on a 24 weekly basis