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It also includes CD38, a membranebound enzyme that depletes NAD+ while regulating calcium signaling and NAMPTs, ratelimiting enzymes in the NAD salvage pathway, essential for maintaining NAD+ levels, and NAD kinase that converts NAD+ into NADP+, and used in anabolic reactions (Campagna and Vignini 2023)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Bhat M, Skill N, Marcus V, Deschenes M, Tan X, Bouteaud J, Negi S, Awan Z, Aikin R, Kwan J, Amre R, Tabaries S, Hassanain M, Seidah NG, Maluccio M, Siegel P, Metrakos P, 2015