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Here is what current evidence and clinical experience suggest

Androgen receptor signalling induced by supraphysiological doses of dihydrotestosterone in human peripheral blood lymphocytes

While side effects such as nausea and dizziness are more common, they are generally manageable and should be weighed against the potential metabolic improvements

We observed that 11.8% of tirzepatide-treated rs1800437-CC carrier individuals experienced vomiting, compared with 9.4% for semaglutide-treated people carrying the same genotype, although the difference was not significant ( P = 0.12, two-sample z -test