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Ultimately though, the antifibrotic effects conferred by compounds derived from TCM target critical signaling nodes such as TGF-/Smad which play pivotal roles in EMT and ECM synthesis (Na et al., 2018) (Figures 2, 3)

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Combination of intermittent hydrostatic pressure linking TGF-beta1, TNF-alpha on modulation of proteoglycan 4 metabolism in rat temporomandibular synovial fibroblasts

Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)