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The Secretary may: Direct agency priorities Encourage enforcement discretion Appoint or replace FDA leadership Order internal review of regulatory positions Support re-evaluation of prior safety determinations The Secretary may not: Bypass statutory requirements Ignore the Administrative Procedure Act Unilaterally legalize peptide compounding Regulatory change must follow defined legal pathways

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Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimers disease

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