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A study showed that repeated and prolonged alcohol administration increases depressive and anxious behaviors in mice, which are associated with reduced iron homeostasis and synaptic plasticity [23]

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Moreover, HSP-70 enhances tumorigenicity and metastasis in murine models and promotes the expression of stemness markers (Nanog, Oct3/4, and SOX2) in stiff hydrogels by increasing the activity of the transcription factor signal transducer and activator of transcription 3 (STAT3) [119]

For instance, an experiment on the effect of probiotics on the structure of tight junction utilized the marker claudin-7 and observed that Lactobacillus plantarum (L