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Peptides stimulate growth factors, encourage collagen production, and recruit stem cells to areas of injury

Canonical HO-1 localises in the endoplasmic reticulum (ER) but the enzyme has been found to localise in other subcellular compartments including mitochondria, vacuoles, nucleus and plasma membrane

Soon after stimulation by an appropriate triggere.g., chemokines/cytokines, pathogen components like lipopolysaccharide (LPS), and/or wounded tissueneutrophils migrate to areas of injury and/or infection and mount an initial innate immune response which requires a rapid metabolic switch dependent on G6PD

Multifactorial basis and therapeutic strategies in metabolism-related diseases