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Photosensitivity refers to an abnormal skin reaction that occurs when certain medications make the skin more susceptible to damage from sun exposure, potentially leading to rashes, burns, or other dermatological reactions at lower UV doses than would normally cause problems

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In dogs, for example, low IGF-1 levels are strongly associated with smaller body size and increased lifespan, whereas larger breeds with higher IGF-1 levels tend to exhibit shorter lifespans and accelerated aging (Sutter et al., 2007