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The secondary IVGTT-related pharmacodynamic (PD) endpoints were the change from baseline to end of treatment in AUC 010min , AUC 10120min and AUC 0120min with respect to C-peptide, insulin secretion rate (ISR), glucagon and insulin (only AUC 0120min )

A study published in the Journal of Medicinal Chemistry identified a compound from fenugreek seeds, designated N55, that binds to GLP-1 and enhances the potency of GLP-1 in stimulating GLP-1 receptor signaling

Finally, enzymes not belonging to either group are categorized as other enzymes. We separated enzymes into these three classes for each dataset and virus using flux balance analysis (see Methods)