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Semaglutide affects blood clotting through multiple pathways, some that could increase risk and others that clearly protect against it

22 Several other studies showed that there was no significant relationship between GLP-1 RAs and DR worsening, including one study by Joo et al in which manual review of the data was conducted to ensure accuracy in the ICD coding used to determine outcomes

Notably, liraglutide treatment significantly inhibited activated sodium-glucose co- transporter-2 (SGLT2) restored depressed insulin receptor substrate 1 (IRS1), and increased protein kinase G (PKG) levels

Modernizing clinical trials for accelerated evidence Clinical trials remain one of the most resource-intensive stages of drug development, often slowed by enrollment challenges, protocol amendments, and limited visibility into real-world care