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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

GLP-1 RAs also reduce blood pressure, improve renal function, reduce chronic inflammation, reduce lipoprotein, reduce chylomicron, increase postprandial triglycerides, increase very-low-density lipoprotein cholesterol (VLDL-C), and increase free fatty acids (20)

206 : 587595 Curti D, Dagani F, Galmozzi MR, Marzatico F

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