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Increased joint discomfort during the first 710 days is occasionally reported and typically reflects increased tissue activity as angiogenesis and fibroblast migration ramp up in previously hypoxic or chronically inflamed areas

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MS/MS spectra of m/z 768.7 representing the unmodified N-terminal peptide of TGF1 at retention time 23.43 min (A) and m/z 877.2 representing a modified form of TGF1 seen only in SF treated samples at retention time 30.85 minutes (B)