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That breadth is exactly what makes retatrutide such a useful research tool, letting scientists probe the triple-receptor action across many endpoints, not just the scale

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For instance, in the SUSTAIN-6 trial, semaglutide was associated with a significantly higher ratio of retinopathy complications compared with placebo, including vitreous hemorrhage, retinal photocoagulation, and intravitreal therapy

Additionally, its ability to improve insulin sensitivity and regulate adipose tissue inflammation makes it an attractive candidate for managing metabolic disorders beyond diabetes, such as non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome