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In particular, G6PD is essential in preserving the integrity of erythrocytes because, lacking mitochondria, they have no other NADPH-generating enzymes to protect against oxidative stress 2

Chem Biol Interact 302:123134 Abdul Rahuman A, Gopalakrishnan G, Venkatesan P, Geetha K (2008) Isolation and identification of mosquito larvicidal compound from Abutilon indicum (Linn.) Sweet

Increased pigmentation also occurs when there is proliferation in the number of normally melanized keratinocytes (epithelial hyperplasia) and/or when there is an increased retention of normally melanized keratinocytes in the stratum corneum

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