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Lenzi A, Sgro P, Salacone P, Paoli D, Gilio B, Lombardo F, et al

Expression of these AR circRNAs was upregulated during castration-resistant progression, with levels of AR circRNAs correlated strongly with those of the linear AR transcripts, indicating a transcriptional mechanism of regulation

While selectivity over classical ERs is reported at relevant concentrations, nuclear-receptor cross-reactivity and downstream network effects remain theoretical risks in longer or higher-exposure studies