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To achieve rapid gelation and controlled redox-triggered dissolution under physiological conditions, orthogonal coupling strategies notably thiolmaleimide and thioldisulfide exchange chemistries have been adopted

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body