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Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible

Redox-sensitive phosphatases include PTP1B, PTEN, and mitogen-associated protein (MAP) or mitogen-activated protein kinase (MAPK) phosphatases, which can be reversibly oxidized by H 2 O 2 , inhibiting their dephosphorylation activity

LX-2 cells in the lower chambers were collected for further analysis

Chaithya, Khushboo Punjabi, Christopher Splaine